The use of THC as a bronchodilator has been studied for some time, and the results have been promising. Acute doses of cannabis and THC have been found to have a definite bronchodilator effect on the small airways of the lungs, though the exact mechanism is still unknown. Studies have suggested that one type of THC may have bronchodilator properties, which could help make breathing easier for people with asthma. In addition to this, THC has anti-inflammatory and antispasmodic properties, which could be beneficial for those with asthma.
Inhaled THC itself could be irritating, as indicated by previously published findings of frequent coughing induced by inhalation of nebulized THC in subjects with asthma. However, the endogenous CB1 agonist anandamide has been shown to inhibit cough caused by capsaicin. It is also assumed that the psychoactive effects of THC, such as euphoria and decreased anxiety, could lead to a reduction in the perception of shortness of breath. In order to further explore the potential benefits of THC as a bronchodilator, it would be advantageous for studies to incorporate modifications to the study design that would mitigate the influence of existing bronchodilator therapy on outcomes, ensure that patients receive an adequate dose of vaporized THC, and exclude patients in whom leg fatigue is the locus of limitation of exercise.
Marijuana contains two main active compounds, delta-9-tetrahydrocannabinol (D-9-THC) and cannabidiol (CBD), as well as 60 cannabinoids and more than 400 compounds in total. CBD, THC, and some other substances in marijuana seem to have several health benefits, including anti-inflammatory and antispasmodic properties. Overall, research into the use of THC as a bronchodilator has been promising so far. Further studies are needed to explore its potential benefits for those with asthma and other respiratory conditions.